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Related Experiment Video

Updated: Jul 13, 2026

Super-resolution Imaging of Neuronal Dense-core Vesicles

Super-resolution Imaging of Neuronal Dense-core Vesicles

Published on: July 2, 2014

Whitish papules on the palm.

Emek Kocatürk¹, Mukaddes Kavala, Nesimi Büyükbabani

¹Department of Dermatology, SB Göztepe Educational Hospital, Istanbul University Faculty of Medicine, Istanbul, Turkey. emekozgur@yahoo.com

International Journal of Dermatology

|July 7, 2007

Summary

Aquagenic syringeal palmar keratoderma causes temporary, whitish, bubbly palms after water exposure. Topical aluminum chloride effectively treated this rare condition.

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Last Updated: Jul 13, 2026

Super-resolution Imaging of Neuronal Dense-core Vesicles

Super-resolution Imaging of Neuronal Dense-core Vesicles

Published on: July 2, 2014

Area of Science:

Dermatology
Histopathology

Background:

Aquagenic syringeal palmar keratoderma (ASPK) is a rare condition characterized by transient palm changes upon water contact.
This case highlights the clinical presentation and histopathological findings of ASPK in a young adult.

Observation:

A 21-year-old woman developed whitish, bubbly palms within minutes of water immersion.
The lesions presented as a sponge-like appearance with tiny white papules and resolved after drying.

Findings:

Histopathology revealed dilated intraepidermal eccrine ducts and a spongy corneal layer.
The clinical and histopathological findings confirmed the diagnosis of aquagenic syringeal palmar keratoderma.

Implications:

Topical aluminum chloride provided a rapid and effective treatment for ASPK.
The condition showed no recurrence after a 1-year follow-up, suggesting a good prognosis with appropriate management.