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Epithelioid hemangioendothelioma with multiple organ involvement
Cigdem Celikel1, P Fulden Yumuk, Gul Basaran
1Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.
Summary
Epithelioid hemangioendothelioma is a rare vascular tumor. This study details two cases of concurrent lung and liver involvement, highlighting diagnostic challenges and treatment approaches for this uncommon condition.
Area of Science:
- Oncology
- Vascular Neoplasms
Background:
- Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor with uncertain malignant potential.
- It frequently presents with multifocal involvement, most commonly affecting the lungs and liver concurrently.
Observation:
- Concurrent involvement of multiple sites, particularly lung and liver, can mimic other neoplastic processes, posing diagnostic challenges.
- Epithelioid hemangioendothelioma is generally chemo-resistant, yet chemotherapy is often recommended for metastatic or multifocal disease.
Findings:
- This report presents two cases of epithelioid hemangioendothelioma with concurrent lung and liver involvement.
- The study documents the clinical presentation, therapeutic interventions, and patient outcomes for these specific cases.
Implications:
- Understanding the diagnostic complexities of multifocal epithelioid hemangioendothelioma is crucial for accurate and timely diagnosis.
- Further research into effective treatment strategies for chemo-resistant epithelioid hemangioendothelioma, especially with combined lung-liver involvement, is warranted.