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Related Experiment Videos

Plasma volume expansion in humans after a single intense exercise protocol.

C M Gillen1, R Lee, G W Mack

  • 1John B. Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1991
PubMed
Summary

Intense exercise expands plasma volume (PV) by increasing plasma albumin content. This albumin increase helps retain fluid, contributing to the overall PV expansion observed post-exercise.

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Area of Science:

  • Exercise Physiology
  • Sports Science
  • Biochemistry

Background:

  • Plasma volume (PV) regulation is crucial for exercise performance and thermoregulation.
  • The role of plasma proteins, particularly albumin, in exercise-induced PV expansion requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between plasma volume expansion and plasma albumin content following intense intermittent exercise.
  • To determine if increased albumin contributes to the observed PV expansion.

Main Methods:

  • Subjects underwent a protocol of intense intermittent exercise (8 x 4 min at 85% maximal O2 uptake).
  • Measurements included plasma volume, plasma total protein, albumin concentration, and osmolality before, during, and at various recovery intervals (1, 2, 24 h).

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  • Plasma volume was assessed using hematocrit, hemoglobin, and Evans blue dye dilution.

    • Main Results:

    • Plasma volume decreased during exercise but expanded by approximately 10% at 24 hours recovery.
    • Plasma albumin and total protein content increased significantly during recovery, with albumin increase accounting for the total protein rise.
    • The calculated increase in albumin could account for a significant portion of the observed plasma volume expansion.

    Conclusions:

    • Intense intermittent exercise leads to a significant expansion of plasma volume within 24 hours.
    • This plasma volume expansion is closely associated with an increase in plasma albumin content.
    • Increased plasma albumin appears to be a key factor in the fluid retention responsible for exercise-induced plasma volume expansion.