Plasma fluorescent oxidation products: independent predictors of coronary heart disease in men

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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Tianying Wu1, Nader Rifai, Walter C Willett

  • 1Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. hptwu@channing.harvard.edu

American Journal of Epidemiology
|July 7, 2007
PubMed

Insights

Plasma fluorescent oxidation products are stable and may predict future coronary heart disease (CHD). Higher levels indicated an increased risk of CHD events in men without prior cardiovascular disease.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Plasma fluorescent oxidation products (FOPs) are stable biomarkers reflecting oxidative stress.
  • Their predictive value for future coronary heart disease (CHD) has not been established.

Purpose of the Study:

  • To investigate whether baseline plasma FOP levels predict incident CHD in men without pre-existing cardiovascular disease.

Main Methods:

  • A nested case-control study design was employed within the Health Professionals Follow-up Study.
  • Baseline plasma FOPs were measured in 266 men with incident CHD and matched controls over 6 years.
  • Multivariate analyses controlled for traditional cardiovascular risk factors.

Main Results:

  • A significant association was observed between higher plasma FOP levels and increased CHD risk (RR 1.83 for extreme quintiles).
  • This association remained significant after adjusting for C-reactive protein and glycated hemoglobin A1c.
  • The risk prediction was stronger in men who fasted for >10 hours (RR 3.36 for extreme quintiles).

Conclusions:

  • Plasma FOPs are significant and independent predictors of future CHD incidence in men.
  • FOPs may serve as a valuable biomarker for assessing cardiovascular risk.

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