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Updated: Jul 13, 2026

Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
Published on: February 11, 2021
JAM family and related proteins in leukocyte migration (Vestweber series)
Paul F Bradfield1, Sussan Nourshargh, Michel Aurrand-Lions
1Department of Pathology and Immunology, University Medical Centre, CH-1211, Geneva 4, Switzerland.
Abstract:
Exploring the role of junctional adhesion molecules (JAMs) has proven to be varied and controversial. The purpose of this review is to discuss the new and exciting roles of these IgSF molecules and how they have evolved to contribute to diverse functions from development to inflammation. In particular, recent research has focused on JAM subfamily members JAM-A, -B, and -C with newly described roles in leukocyte trafficking during inflammation and angiogenesis. However, research on all JAM family members has demonstrated recurring themes with striking similarities in the many diverse processes they are now known to regulate.
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