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The Parathyroid Glands

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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The Thyroid Gland

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Related Experiment Video

Updated: Jul 13, 2026

"Sun's Seven-Step Technique" for Endoscopic En-Bloc Resection of Thyroid Cancer via the Chest-Breast Approach

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Heterotopic parathyroid inclusion in a cervical lymph node.

Emanuela Veras¹, Erich M Sturgis, Mario A Luna

¹Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, Texas, USA.

|July 7, 2007

Summary

Pathologists discovered benign parathyroid tissue within a cervical lymph node during neck dissection for laryngeal cancer. This rare finding highlights the importance of considering heterotopic parathyroid inclusions in diagnoses.

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Area of Science:

Pathology
Surgical Oncology
Endocrinology

Background:

Neck dissection specimens can reveal unexpected findings, including benign epithelial inclusions.
Differential diagnoses for intranodal epithelial inclusions are broad.

Observation:

A 59-year-old man underwent laryngectomy and bilateral neck dissection for laryngeal squamous cell carcinoma.
A significantly enlarged lymph node (2.5 x 2.2 x 0.8 cm) was identified at right level IV.

Findings:

Histologic examination confirmed benign parathyroid inclusions within the enlarged lymph node.
Immunohistochemistry revealed parathyroid hormone expression in the heterotopic cells.
This represents a unique case of parathyroid tissue found within a cervical lymph node.

Implications:

Heterotopic parathyroid inclusions should be considered in the differential diagnosis of cervical lymph node pathology.
Accurate identification is crucial to avoid misdiagnosis and ensure appropriate patient management.