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Updated: Jul 13, 2026
08:22
A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Unique persistent neurological sequelae of heat stroke.
Moshe Rav-Acha1, Mony Shuvy, Shalom Hagag
1Internal Medicine A Department, Hadassah Medical School, Jerusalem, Israel.
Military Medicine
|July 10, 2007
Summary
Severe heat stroke can cause lasting brain damage, but this case showed unusual frontal lobe issues instead of the typical cerebellar problems. This challenges our understanding of heat stroke
Area of Science:
- Neurology
- Toxicology
- Critical Care Medicine
Background:
- Heat stroke is a severe condition causing systemic heat and cytokine-induced organ damage.
- Permanent neurological deficits are rare after heat stroke, often involving cerebellar dysfunction.
Observation:
- This case involved severe heat stroke with multiorgan failure, followed by persistent neurological issues.
- The patient exhibited resolving right-sided signs and persistent frontal subcortical dysfunction.
Findings:
- Unlike typical cases, cerebellar involvement was minimal or absent.
- The neurological sequelae presented an unusual combination of frontal and resolving lateralized deficits.
Implications:
- This case highlights the diverse and potentially atypical neurological manifestations of severe heat stroke.
- Further research is needed to understand the mechanisms behind varied neurological outcomes in heat stroke patients.
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