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Related Experiment Video

Updated: Jul 13, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

[Diet-induced obesity affects testis development in pubertal rats].

Yong Wang¹, Xiao-ping Liu, Da-nian Qin

¹Department of Physiology, Shantou University Medical College, Guangdong, China. yongwang@stu.edu.cn

Zhonghua Nan Ke Xue = National Journal of Andrology

|July 10, 2007

Summary

A high-fat diet induced obesity in pubertal rats, negatively impacting testicular development and hormone levels. This study highlights the adverse effects of nutritional obesity on male reproductive health.

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Last Updated: Jul 13, 2026

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

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Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

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Fat Preference: A Novel Model of Eating Behavior in Rats

Fat Preference: A Novel Model of Eating Behavior in Rats

Published on: June 27, 2014

Area of Science:

Reproductive Endocrinology
Developmental Toxicology
Nutritional Science

Context:

Diet-induced obesity is a growing concern with potential health implications.
Pubertal development is a critical window for reproductive system maturation.

Purpose:

To investigate the impact of a high-fat diet on the development of testes in pubertal rats.
To assess changes in body weight, reproductive organ weights, and hormone levels.

Summary:

Male rats fed a high-fat diet exhibited increased body weight and Lee's index compared to controls.
Testicular coefficient decreased, while plasma triglycerides and cholesterol increased in the high-fat group.
Testosterone levels decreased, and estradiol showed a biphasic change, with testicular histology revealing disordered spermatogenesis.

Impact:

High-fat diet-induced obesity can lead to testicular underdevelopment in pubertal rats.
Abnormal gonadal hormone levels are associated with impaired testicular function.
Findings suggest potential risks to male reproductive health from obesogenic diets during development.