Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Unraveling antibiotic fate in a highly urbanized estuary: Spatiotemporal patterns, multi-media partitioning, and contaminant prioritization.

Marine pollution bulletin·2026

Same author

Exploration of prognosis and immune infiltration characteristics in glioblastoma multiforme based on lipid metabolism related genes.

Discover oncology·2025

Same author

Perioperative blood transfusion and the prognosis of ovarian cancer surgery: A meta-analysis.

Pakistan journal of medical sciences·2025

Same author

Food web bioaccumulation model for ecological risk assessment of emerging organic pollutants in marine ecosystems: Principles, advances and challenges.

Environmental pollution (Barking, Essex : 1987)·2024

Same author

Prognostic significance of oligodendrocyte transcription factor 2 expression in glioma patients: A systematic review and meta-analysis.

World journal of clinical cases·2024

Same author

Organophosphate flame retardants and their metabolites in the Pearl River Estuary: Occurrence, influencing factors, and ecological risk control strategies based on a mass balance model.

Environment international·2024

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Medium-throughput Screening Assays for Assessment of Effects on Ca²⁺-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

[Effect of platelet-activating factor on sperm function].

Qian-yi Huang¹, Mu-jun Li

¹Research Center of Reproductive Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. qyhuang@gxmu.net.cn

Zhonghua Nan Ke Xue = National Journal of Andrology

|July 10, 2007

Summary

Platelet-activating factor (PAF), a signaling phospholipid, is crucial for male reproduction and sperm function. Measuring sperm-derived PAF can predict fertility potential and improve outcomes in human inseminations.

More Related Videos

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Published on: December 30, 2014

Related Experiment Videos

Last Updated: Jul 13, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm

Medium-throughput Screening Assays for Assessment of Effects on Ca²⁺-Signaling and Acrosome Reaction in Human Sperm

Published on: March 1, 2019

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

Published on: December 30, 2014

Area of Science:

Biochemistry
Reproductive Biology
Cell Signaling

Context:

Platelet-activating factor (PAF) is a signaling phospholipid with diverse biological functions.
Emerging research highlights PAF's significant role in male reproductive processes and sperm functionality.
PAF signaling involves receptor binding, inositol triphosphate (IP3) and diacylglycerol (DAG) production, and calcium influx.

Purpose:

To investigate the role of sperm-derived Platelet-activating factor (PAF) in male fertility.
To explore PAF's potential as a biomarker for sperm motility and fertilization capacity.
To evaluate the effects of exogenous PAF on sperm function and pregnancy rates in human intrauterine inseminations.

Summary:

Sperm-derived PAF concentrations correlate with sperm motility and fertilization potential, suggesting its utility as a male fertility marker.
Exogenous administration of PAF has demonstrated improvements in sperm motility and acrosome reaction.
PAF treatment in human intrauterine inseminations has shown enhanced pregnancy rates.

Impact:

This research identifies PAF as a potential diagnostic marker for male infertility.
The findings suggest therapeutic applications of PAF to enhance reproductive success in assisted reproductive technologies.
Understanding PAF's mechanism in sperm function can lead to novel strategies for fertility treatment.