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A new flavonoid glycoside from the leaf of Cephalotaxus koreana
Kihwan Bae1, Wenyi Jin, Phuong Thien Thuong
1College of Pharmacy, Chungnam National University, Daejeon, South Korea. baekh@cnu.ac.kr
Abstract:
A new flavone glycoside, apigenin 5-O-alpha-L-rhamnopyranosyl-(1-->3)-beta-D-glucopyranoside (1), along with four known flavonol glycosides (2-5), were isolated from the leaf of Cephalotaxus koreana. The new glycoside 1 showed inhibitory activity in superoxide radical scavenging assay with IC(50) value of 13.0 microM, while it showed weak activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Compounds 2-5 exhibited antioxidant activity in scavenging DPPH and superoxide radicals with IC(50) values ranging from 5.7 to 22.3 microM.
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