Chronic hepatitis C virus infection: a review for pharmacists

To review the epidemiology, pathophysiology, and therapeutics of chronic hepatitis C virus (HCV) infection, focusing on patient counseling and adverse effects, to serve as a resource for pharmacists in multiple patient care settings.

Published articles identified through Medline using search terms such as hepatitis C virus, hepacivirus, ribavirin, interferon alfa-2a, or interferon alfa-2b. Therapeutic guidelines retrieved from www.guidelines.gov and the Centers for Disease Control and Prevention (CDC). Additional resources identified from personal bibliographies collected by the author and bibliographies from gathered articles.

By the author.

By the author.

HCV is a blood-borne pathogen affecting an estimated 4 million Americans and 170 million people worldwide. An estimated two-thirds to three-fourths of those infected with HCV have not been diagnosed, and in the next 10 to 20 years, the number of patients diagnosed with HCV is likely to increase. Thus, the health care community, including pharmacists, needs to be educated about the disease, how it is spread, and the details related to treatment of HCV. The standard therapy for HCV is combination therapy with pegylated interferon and ribavirin. This therapy has a varied rate of response that improves with medication adherence. Adherence is often reduced as a result of adverse effects of therapy. In this article, a basic review of HCV is provided, as well as a thorough discussion of strategies to reduce the incidence and severity of adverse effects related to therapy.

Pharmacists have an important role in educating other health care practitioners and the community about HCV, providing injection training and medication and adverse effect counseling for patients initiating therapy, and engaging in follow-up and monitoring of patients to encourage therapeutic success by improving medication adherence and patient tolerance of adverse effects.