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Related Experiment Videos

Does ovarian stimulation for in-vitro fertilization induce a hypercoagulable state?

B Aune1, K E Høie, P Oian

  • 1Department of Obstetrics and Gynaecology, University of Tromsø, Norway.

Human Reproduction (Oxford, England)
|August 1, 1991
PubMed
Summary

Ovarian stimulation for in-vitro fertilization (IVF) significantly increases blood fibrinogen and reduces antithrombin III levels. This suggests IVF hormonal treatments may induce a hypercoagulable state, impacting blood clot formation and lysis.

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Area of Science:

  • Reproductive Endocrinology
  • Hematology
  • Clinical Biochemistry

Background:

  • Ovarian stimulation is a key component of in-vitro fertilization (IVF).
  • Hormonal interventions during IVF aim to enhance oocyte yield.
  • Potential systemic effects of these interventions, particularly on hemostasis, require thorough investigation.

Purpose of the Study:

  • To evaluate the impact of ovarian stimulation on blood coagulation and fibrinolytic activity in women undergoing IVF.
  • To assess changes in specific hemostatic markers, including fibrinogen, antithrombin III, and factor VII.
  • To determine if ovarian stimulation for IVF induces a prothrombotic state.

Main Methods:

  • Prospective study involving 12 women undergoing ovarian stimulation for IVF.

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  • Blood samples collected before stimulation (days 2-3) and after human chorionic gonadotrophin (HCG) administration (days 10-12).
  • Assays included whole blood clotting time, clot lysis time, plasma fibrinogen, antithrombin III, and factor VII levels.

    • Main Results:

    • A significant increase in plasma fibrinogen (P < 0.001) and a significant reduction in antithrombin III (P < 0.001) were observed post-stimulation.
    • Blood fibrinolytic activity was significantly reduced, indicated by increased clot lysis time (P < 0.02).
    • Whole blood clotting time showed a non-significant trend towards shortening; factor VII levels remained unchanged.

    Conclusions:

    • Ovarian stimulation for IVF is associated with significant alterations in hemostatic parameters.
    • The observed changes, specifically increased fibrinogen and decreased antithrombin III, suggest a shift towards a hypercoagulable state.
    • These findings highlight the potential hemostatic risks associated with IVF protocols that warrant further clinical consideration.