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Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease
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High-sensitivity C-reactive protein concentration in patients with myocardial infarction-environmental factors, and

Alena Lorenzová1, Vladimír Stanek, Marie Gebauerová

  • 1Cardiocentre, Department of Cardiology, 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic. alena.lorenzova@akademon.cz

Clinical Chemistry and Laboratory Medicine
|July 10, 2007
PubMed

Insights

High-sensitivity C-reactive protein (hsCRP) levels are higher in myocardial infarction patients. Gene-environment interactions, not specific gene polymorphisms, appear to influence hsCRP concentrations.

Area of Science:

  • Cardiology
  • Genetics
  • Biochemistry

Background:

  • Elevated high-sensitivity C-reactive protein (hsCRP) is linked to myocardial infarction (MI) risk.
  • Mechanisms regulating hsCRP levels, particularly genetic and environmental factors, require further elucidation.
  • This study investigates the association of interleukin-10 (IL-10) and CD14 gene polymorphisms and environmental factors with MI risk and hsCRP levels.

Purpose of the Study:

  • To examine the relationship between IL-10 and CD14 polymorphisms and myocardial infarction.
  • To investigate the influence of environmental factors on hsCRP concentrations in MI patients and controls.
  • To explore potential gene-environment interactions affecting hsCRP levels.

Main Methods:

  • A case-control study involving 284 male MI patients under 65 and age-matched male controls from a population sample.
  • Analysis of interleukin-10 (IL-10) and CD14 genotype distributions.
  • Measurement of hsCRP concentrations and assessment of environmental factors including smoking, BMI, obesity, and statin treatment.

Main Results:

  • MI patients exhibited higher hsCRP concentrations (2.12 mg/L) compared to controls (1.40 mg/L), despite widespread statin use.
  • No significant differences in IL-10 or CD14 genotype frequencies were observed between patients and controls.
  • Smoking in conjunction with the CD14 C allele was associated with significantly higher hsCRP levels (p=0.0012).
  • Linear regression indicated statin treatment influenced hsCRP in patients, while age, smoking, education, and BMI affected hsCRP in controls.

Conclusions:

  • IL-10 and CD14 polymorphisms are not directly associated with myocardial infarction occurrence.
  • Gene-environment interactions play a significant role in modulating hsCRP concentrations.
  • Environmental factors, such as smoking and BMI, interact with genetic predispositions to influence hsCRP levels, impacting cardiovascular risk.
Abstract

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