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Related Experiment Video

Updated: Jul 13, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Dynamic changes in T-wave amplitude during tilt table testing: correlation with outcomes.

Kenneth A Mayuga1, Fetnat Fouad-Tarazi

  • 1Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH, USA.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|July 10, 2007
PubMed
Summary

Dynamic T-wave changes during head-up tilt table (HUT) testing correlate with specific autonomic responses. These ECG findings are linked to postural orthostatic tachycardia syndrome (POTS) and vasovagal response (VVR).

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Area of Science:

  • Cardiology
  • Autonomic Neuroscience
  • Electrocardiography

Background:

  • Autonomic tone influences cardiac repolarization and may play a role in syncope.
  • Electrocardiogram (ECG) T-wave changes during head-up tilt table (HUT) testing have an unclear significance.
  • Understanding these T-wave alterations can provide insights into autonomic dysfunction.

Purpose of the Study:

  • To investigate the relationship between dynamic T-wave changes during HUT testing and various syncope outcomes.
  • To determine if T-wave alterations correlate with specific autonomic conditions like POTS and VVR.
  • To analyze the influence of age and gender on these ECG findings.

Main Methods:

  • Reviewed 12-lead ECGs from 150 patients undergoing HUT testing.

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Last Updated: Jul 13, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

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Published on: March 21, 2013

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Published on: July 19, 2011

  • Recorded T-wave changes (amplitude decrease, inversion) during supine, tilt, and recovery phases.
  • Correlated T-wave alterations in specific ECG leads with HUT outcomes: nondiagnostic, POH, POTS, and VVR.

    • Main Results:

    • 135 of 150 patients exhibited T-wave changes during HUT, mostly in inferior and anterolateral leads.
    • T-wave changes in V1 inversely correlated with postural orthostatic hypotension (POH).
    • T-wave changes in inferior and anterolateral leads positively correlated with postural orthostatic tachycardia syndrome (POTS); female gender and younger age also linked to POTS.
    • T-wave changes in leads V5, V6, and aVF correlated with vasovagal response (VVR).

    Conclusions:

    • Dynamic T-wave changes during HUT testing are significantly associated with POTS and VVR.
    • These ECG findings are independent of patient age and gender.
    • Further research is warranted to explore the role of autonomic tone in these observed T-wave alterations.