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Related Experiment Videos

Orthostatic function during a stand test before and after head-up or head-down bedrest.

C M Lathers1, P H Diamandis, J M Riddle

  • 1Universities Space Research Association, Division of Space Biomedicine, Houston, Texas 77058.

Journal of Clinical Pharmacology
|October 1, 1991
PubMed
Summary

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Simulating space flight with short-term bedrest reveals significant orthostatic intolerance, particularly after -5 degrees tilt. This highlights the impact of altered gravity on cardiovascular regulation and astronaut health.

Area of Science:

  • Cardiovascular Physiology
  • Space Medicine
  • Human Physiology

Background:

  • Astronauts often experience orthostatic dysfunction upon returning to Earth's gravity.
  • Understanding cardiovascular adaptations to microgravity is crucial for mitigating spaceflight-related health risks.
  • Short-duration bedrest serves as a model to simulate some physiological effects of spaceflight.

Purpose of the Study:

  • To investigate the effects of short-term, head-down bedrest on orthostatic tolerance in young adults.
  • To compare cardiovascular responses during a stand test after different degrees of simulated gravity exposure.
  • To identify bedrest conditions that best mimic the orthostatic intolerance observed after space flight.

Main Methods:

  • Young male adults underwent 6-hour bedrest sessions at -5, +10, +20, and +42 degrees.
Keywords:
NASA Center JSCNASA Discipline CardiopulmonaryNASA Discipline Number 14-10NASA Program Space Physiology and Countermeasures

Related Experiment Videos

  • A stand test (5 minutes supine, 5 minutes standing) was performed before and after each bedrest session.
  • Cardiovascular parameters including heart rate and mean arterial pressure were continuously monitored.

    • Main Results:

    • Orthostatic intolerance, characterized by nausea and lightheadedness, was reported after -5 and +10 degrees bedrest.
    • Heart rate significantly increased upon standing post-bedrest, with a notable 11 bpm increase after -5 degrees tilt.
    • Mean arterial pressure changes were minimal, but the stand test results post -5 degrees bedrest resembled those after actual space flight.

    Conclusions:

    • Short-term head-down bedrest, especially at -5 degrees, can induce orthostatic intolerance similar to that experienced after space flight.
    • This bedrest model provides valuable insights into the mechanisms underlying cardiovascular deconditioning during space missions.
    • Further research is warranted to explore countermeasures for orthostatic dysfunction in astronauts.