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Eclampsia in the United Kingdom 2005.

M Knight1,

  • 1National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK. marian.knight@npeu.ox.ac.uk

BJOG : an International Journal of Obstetrics and Gynaecology
|July 10, 2007
PubMed
Summary

The UK incidence of eclampsia is 2.7 per 10,000 births, with no maternal deaths reported following magnesium sulphate treatment. This indicates a significant decrease in eclampsia complications since 1992.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal Health
  • Neurology

Background:

  • Eclampsia remains a significant cause of maternal morbidity and mortality worldwide.
  • The introduction of magnesium sulphate has been a cornerstone in managing pre-eclampsia and eclampsia.
  • Understanding current national incidence and outcomes is crucial for refining obstetric care.

Purpose of the Study:

  • To determine the national incidence of eclampsia in the UK.
  • To describe the management strategies employed for eclampsia.
  • To assess the maternal and perinatal outcomes following eclampsia since the widespread adoption of magnesium sulphate.

Main Methods:

  • A population-based descriptive study utilizing the UK Obstetric Surveillance System (UKOSS).

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  • Prospective case identification across all 229 UK consultant-led maternity units.
  • Data collected for women delivering between February 2005 and February 2006.

    • Main Results:

    • The incidence of eclampsia was 2.7 cases per 10,000 births.
    • Ninety-nine percent of women received magnesium sulphate; no maternal deaths occurred.
    • Significant rates of recurrent fits (26%), intensive care admission (56%), and severe morbidity (10%) were observed.
    • Perinatal mortality was 59/1000 births.

    Conclusions:

    • Eclampsia incidence and complications have decreased in the UK since 1992, correlating with management guidelines and magnesium sulphate use.
    • Findings support the efficacy of magnesium sulphate as demonstrated in randomized controlled trials.
    • The study highlights the successful integration of research evidence into clinical practice for improved maternal outcomes.