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Updated: Jul 13, 2026

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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Lepidepyrone, a new gamma-pyrone derivative, from Neolentinus lepideus, inhibits hyaluronidase
Tomoo Hosoe1, Hideo Sakai, Makoto Ichikawa
1Faculty of Pharmaceutical Sciences, Hoshi University, Ebara, Tokyo, Japan. kawai@hoshi.ac.jp
The Journal of Antibiotics
|July 10, 2007
Abstract:
In the course of screening for hyaluronidase (HAase) inhibitory agents, a new gamma-pyrone derivative, lepidepyrone, C(8)H(10)O(5), was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound (IC(50) 3.3 mM). The structure of lepidepyrone was established on the basis of spectroscopic investigation.

