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Updated: Jul 13, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Outcomes of unexplained syncope in the elderly.

Oleg Roussanov¹, Greta Estacio, Maribeth Capuno

¹Veterans Affairs Medical Center, Salem, VA 24153, USA.

The American Journal of Geriatric Cardiology

|July 10, 2007

Summary

Syncope of unknown etiology (SUE) in elderly patients does not increase mortality risk. Inpatient status was the only factor linked to higher mortality, not SUE itself.

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Last Updated: Jul 13, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Area of Science:

Geriatrics
Cardiology
Epidemiology

Background:

Syncope is a common condition in the elderly, often with an unknown cause.
Understanding the prognostic implications of syncope of unknown etiology (SUE) in older adults is crucial for clinical management.

Purpose of the Study:

To investigate whether syncope of unknown etiology (SUE) independently influences all-cause mortality in elderly individuals (≥65 years).

Main Methods:

Retrospective cohort study comparing elderly patients with SUE to an age-, sex-, and comorbidity-matched control group.
All-cause 3-year mortality was analyzed using Kaplan-Meier survival analysis and log-rank tests.
Cox proportional hazards models were used to identify predictors of mortality.

Main Results:

Syncope of unknown etiology (SUE) was diagnosed in 49% of the syncope patients studied.
No significant difference in 3-year all-cause mortality was observed between patients with SUE and the control group (147.8 vs 153.4 per 1000 person-years, P=.7).
Inpatient status among SUE patients was associated with a significantly higher risk of all-cause mortality (adjusted hazard ratio: 2.2, P=.017).

Conclusions:

New-onset syncope of unknown etiology (SUE) is not an independent predictor of mortality in elderly patients.
Inpatient status is a significant risk factor for mortality in elderly patients presenting with syncope of unknown etiology.
Further research may focus on risk stratification within the inpatient SUE population.