Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Positively charged microemulsions for topical application.

Elena Peira1, M Eugenia Carlotti, Chiara Trotta

  • 1Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, 10125 Turin, Italy.

International Journal of Pharmaceutics
|July 10, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Albumin Nanoparticles Improve Colistin Performance Against Hetero- and Full-Resistant Clinical <i>A. baumannii</i>: A Mechanistic Study.

Antibiotics (Basel, Switzerland)·2026
Same author

Exploiting Greener Formulations of Benzalkonium Chloride with Enhanced Antibacterial Properties.

ACS omega·2026
Same author

Maltodextrins functionalised with pyrrolidine nitroxides: Synthesis and in vivo follow-up by magnetic resonance imaging.

International journal of biological macromolecules·2026
Same author

pH-Sensitive Dextrin-Based Nanosponges Crosslinked with Pyromellitic Dianhydride and Citric Acid: Swelling, Rheological Behavior, Mucoadhesion, and In Vitro Drug Release.

Gels (Basel, Switzerland)·2026
Same author

Erratum to "Gemcitabine-loaded ICOS-Fc decorated nanosponges: a new chemo immunotherapy combination against pancreatic cancer". [Int. J. Pharm. 682 (2025) 125869].

International journal of pharmaceutics·2026
Same author

Exploring Anti-Neoplastic Activity of Chitosan Nanobubbles Decorated with ICOS-Fc and Loaded with Paclitaxel in a Human and Murine Model of Melanoma.

Pharmaceutics·2025

Positively charged microemulsions enhance miconazole nitrate (MCZ) skin accumulation without increasing systemic absorption. L-alanine benzyl ester (ALAB) is identified as a suitable cationic agent for optimized drug delivery.

Area of Science:

  • Dermatology and Pharmaceutical Sciences
  • Colloid and Surface Chemistry

Background:

  • Microemulsions offer potential for topical drug delivery.
  • Controlling drug accumulation and permeation in the skin is crucial for efficacy and safety.

Purpose of the Study:

  • To investigate the in vitro pig-skin permeation and accumulation of miconazole nitrate (MCZ) from positively charged microemulsions.
  • To evaluate the impact of different cationic charge-inducing agents on MCZ delivery.

Main Methods:

  • Formulation of positively charged microemulsions with varying components and cationic agents (stearylamine, ALAB, CTAB).
  • Characterization of microemulsions by zeta-potential and droplet size analysis.
  • In vitro permeation and accumulation studies using pig skin over 24 hours.

Related Experiment Videos

Main Results:

  • Negligible in vitro skin permeation of MCZ observed for all formulations.
  • Positively charged microemulsions showed nearly double the MCZ accumulation compared to negatively charged counterparts.
  • L-alanine benzyl ester (ALAB) demonstrated suitability as a cationic charge-inducing agent.

Conclusions:

  • Positively charged microemulsions can enhance skin drug targeting of MCZ without systemic absorption.
  • The interaction between positively charged microemulsions and negatively charged skin contributes to increased accumulation.
  • ALAB is a promising cationic agent for developing targeted topical drug delivery systems.