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Evaluation of a muscle relaxant on sequelae of third molar surgery: a pilot study

Robert Kirmeier1, Astrid Truschnegg, Michael Payer

  • 1Department of Oral Surgery and Radiology, School of Dental Medicine, Medical University of Graz, Graz, Austria. robert.kirmeier@meduni-graz.at

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
|July 10, 2007
PubMed
Abstract

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Peripherally and Centrally Acting Muscle Relaxants: A Comparison

Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
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Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
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