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Related Experiment Videos

Circulating soluble interleukin 2 receptor concentration is increased in both immunogenic and nonimmunogenic

S Mariotti1, P Caturegli, G Barbesino

  • 1Istituto di Endocrinologia, University of Pisa, Italy.

Journal of Endocrinological Investigation
|October 1, 1991
PubMed
Summary

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Soluble interleukin-2 receptor (sIL-2R) levels are elevated in untreated hyperthyroidism, correlating with thyroid hormone levels. Treatment normalizes sIL-2R, indicating thyroid function, not just autoimmunity, influences this marker.

Area of Science:

  • Endocrinology
  • Immunology
  • Clinical Chemistry

Background:

  • Soluble interleukin-2 receptor (sIL-2R) signifies T lymphocyte activation.
  • Elevated sIL-2R is noted in Graves' disease, suggesting autoimmunity.
  • The role of thyroid function in sIL-2R levels was previously uninvestigated.

Purpose of the Study:

  • To investigate sIL-2R concentrations in patients with hyperthyroidism.
  • To determine the relationship between sIL-2R levels and thyroid function.
  • To assess if thyroid status influences sIL-2R levels in both autoimmune and non-autoimmune hyperthyroidism.

Main Methods:

  • Assayed serum sIL-2R using ELISA in normal subjects and hyperthyroid patients.
  • Compared sIL-2R levels in untreated Graves' disease (GD) and toxic adenoma (TA) patients versus controls.

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  • Monitored sIL-2R levels after achieving euthyroid state through treatment.

    • Main Results:

    • Significantly increased sIL-2R in untreated GD and TA patients compared to normal controls.
    • Normalization of sIL-2R levels after treatment restored euthyroid state in both GD and TA groups.
    • A strong positive correlation was observed between serum sIL-2R and free triiodothyronine (FT3) and free thyroxine (FT4) levels.

    Conclusions:

    • Serum sIL-2R levels are elevated in hyperthyroidism, irrespective of its autoimmune or non-autoimmune origin.
    • Thyroid hormone levels (FT3, FT4) are positively correlated with sIL-2R concentrations.
    • sIL-2R normalization upon achieving euthyroidism suggests thyroid function significantly impacts sIL-2R levels.