Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma.

Karl Andreas Schlegel1, Robert Zimmermann, Michael Thorwarth

  • 1Department of Oral Maxillofacial Surgery, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany. andreas.schlegel@yahoo.de

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
|July 10, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phosphoprotein Profile of Ameloblastoma.

Asian Pacific journal of cancer prevention : APJCP·2025
Same author

Follow-up of idiopathic osteosclerosis on cone-beam computed tomography: a retrospective longitudinal study.

Scientific reports·2025
Same author

A study of risk factors associated with the presence of oral potentially malignant disorders: a community-based study from Northeastern Thailand.

BMC oral health·2024
Same author

Prevalence of Xerostomia and Hyposalivation Among Individuals Attending Oral Cancer Screening in Thailand: A Cross-Sectional Study.

Journal of International Society of Preventive & Community Dentistry·2024
Same author

Expression of CLLD7 and CHC1L Proteins in Oral Epithelial Dysplasia in a Group of Thai Patients.

Asian Pacific journal of cancer prevention : APJCP·2024
Same author

Exploring protein profiles and hub genes in ameloblastoma.

Biomedical reports·2024

Platelet-rich plasma (PRP) did not significantly enhance bone formation when combined with autogenous bone or a bovine bone substitute in sinus augmentation procedures. This study found no added benefit of PRP in promoting early bone development.

Area of Science:

  • Oral and Maxillofacial Surgery
  • Regenerative Dentistry
  • Biomaterials Science

Background:

  • Sinus augmentation is crucial for severe alveolar ridge atrophy.
  • Autogenous bone grafts have donor site complications.
  • Bone substitutes and platelet-rich plasma (PRP) show potential for bone regeneration.

Purpose of the Study:

  • To investigate the efficacy of platelet-rich plasma (PRP) combined with autogenous bone versus a bovine bone substitute in sinus augmentation.
  • To evaluate the impact of PRP on early bone formation in a split-mouth animal model.

Main Methods:

  • A split-mouth study was conducted on minipigs.
  • Sinus augmentation was performed using a lateral approach with three implants per site.
  • Groups were randomized to receive autogenous bone alone, autogenous bone with PRP, bovine hydroxyapatite alone, or bovine hydroxyapatite with PRP.

Related Experiment Videos

Main Results:

  • No significant difference in bone formation rates was observed between autogenous bone alone and autogenous bone with PRP.
  • Platelet-rich plasma (PRP) showed a nonsignificant effect with bovine hydroxyapatite at 8 weeks.
  • No significant influence of PRP was found at other observation periods for either grafting material.

Conclusions:

  • Platelet-rich plasma (PRP) did not demonstrate a significant influence on bone formation in sinus augmentation procedures, regardless of the bone grafting material used.
  • The addition of PRP to autogenous bone or bovine hydroxyapatite did not yield statistically significant improvements in early bone regeneration in this study.