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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Related Experiment Video

Updated: Jul 13, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Crohn's disease and its mucocutaneous involvement.

Eleonora Ruocco1, Antonio Cuomo, Raffaele Salerno

  • 1Department of Dermatology, Second University of Naples, Naples, Italy.

Skinmed
|July 10, 2007
PubMed
Summary

Crohn's disease (CD) is a chronic inflammatory disorder affecting the gastrointestinal tract and potentially other organs. Diagnosis relies on clinical, endoscopic, radiologic, and histopathologic findings, with treatment focusing on managing acute phases and preventing relapse.

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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Dermatology

Background:

  • Crohn's disease (CD) is a chronic inflammatory disorder with unknown etiology.
  • It primarily affects the lower gastrointestinal tract but can involve skin, musculoskeletal system, and eyes.
  • Pathologic features include skip lesions, aphthous ulceration, and fistulation due to granulomatous transmural inflammation.

Purpose of the Study:

  • To summarize the understanding of Crohn's disease, including its manifestations, diagnosis, and treatment.
  • To highlight the classification of cutaneous and oral lesions associated with CD.
  • To outline current therapeutic strategies for managing Crohn's disease.

Main Methods:

  • Review of clinical, endoscopic, radiologic, and histopathologic features of Crohn's disease.
  • Classification of specific and nonspecific cutaneous and oral manifestations.
  • Summary of therapeutic approaches, including conventional and biologic agents.

Main Results:

  • Crohn's disease presents with characteristic pathologic findings in the gastrointestinal tract.
  • Cutaneous and oral lesions in CD can be classified as specific (granulomatous) or nonspecific.
  • Diagnosis integrates multiple assessment modalities.
  • Therapy involves mesalazine, corticosteroids, immunosuppressants, and anti-tumor necrosis factor-alpha antibodies.

Conclusions:

  • Crohn's disease is a complex inflammatory disorder with diverse manifestations.
  • Accurate diagnosis requires a multidisciplinary approach.
  • Current therapies aim to control disease activity and prevent relapse, with emerging biologic treatments offering new options.