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Gallbladder abnormalities in acute viral hepatitis: a prospective ultrasound evaluation
1Department of Gastroenterology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
Journal of Clinical Gastroenterology
|December 1, 1991
Summary
Sonographic abnormalities are common in acute viral hepatitis (AVH), with nearly all patients showing changes. These ultrasound findings typically resolve within 12 weeks, coinciding with clinical recovery.
Area of Science:
- Radiology
- Hepatology
- Internal Medicine
Background:
- Acute viral hepatitis (AVH) presents with diverse clinical and biochemical profiles.
- Sonographic findings in AVH are not well-characterized regarding their temporal evolution and resolution patterns.
Purpose of the Study:
- To evaluate the temporal sequence and resolution patterns of sonographic abnormalities in acute viral hepatitis.
- To correlate sonographic findings with clinical and biochemical profiles during AVH.
Main Methods:
- Prospective case-controlled study involving 56 patients with AVH within 2 weeks of illness onset.
- Real-time ultrasound examinations were performed weekly until clinical and biochemical resolution.
- Analysis of sonographic parameters including wall thickness, luminal abnormalities, and volume alterations.
Main Results:
- Abnormal sonographic patterns were detected in 98.2% of patients.
- Gallbladder wall thickening (>7 mm) and abnormal luminal contents were more frequent in patients assessed within 1 week of illness onset (p<0.05).
- Complete sonographic resolution occurred in 96.4% of patients by 12 weeks, with no significant correlations found between sonographic patterns and clinical/biochemical profiles.
Conclusions:
- Sonographic abnormalities are highly prevalent in AVH and typically resolve with clinical recovery.
- Early ultrasound assessment (within 1 week) may reveal more pronounced gallbladder wall thickening and luminal abnormalities.