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Published on: January 7, 2019
Identification of chicken anemia virus putative intergenotype recombinants.
Cheng-Qiang He1, Nai-Zheng Ding, Wei Fan
1College of Life Science, Shandong Normal University, Jinan 250014, China. hchqiang@yahoo.com.cn
Virology
|July 10, 2007
Summary
Homologous recombination between chicken anemia virus (CAV) strains was investigated. Two mosaic CAV strains, identified through phylogenetic analysis, suggest recombination contributes to the genetic diversity of this important poultry pathogen.
Area of Science:
- Virology
- Molecular Biology
- Genetics
Background:
- Chicken anemia virus (CAV) is the sole member of the Gyrovirus genus within the Circoviridae family, causing infectious anemia in chickens.
- The potential for homologous recombination between different CAV strains has not been previously explored.
Purpose of the Study:
- To investigate the occurrence of homologous recombination among chicken anemia virus (CAV) strains.
- To understand the role of recombination in generating genetic diversity within natural CAV populations.
Main Methods:
- Phylogenetic analysis of full-length CAV strains was conducted to identify potential recombination events.
- The SimPlot program was utilized to detect and analyze recombinant sequences.
Main Results:
- Two putative recombinant CAV strains (SD24 and SD22) were identified, along with their parental-like strains.
- These mosaic CAV strains represent a novel genotype within the existing phylogenetic framework.
- The findings indicate the presence of homologous recombination in CAV.
Conclusions:
- Homologous recombination appears to be an active process in the evolution of chicken anemia virus.
- Recombination plays a significant role in generating genetic diversity within natural CAV populations, potentially impacting viral evolution and epidemiology.
