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The clinical application of metabolic therapy for cardiovascular disease
Anthony Hadj1, Salvatore Pepe, Franklin Rosenfeldt
1Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital and Baker Heart Research Institute, Victoria, Australia.
Abstract:
Metabolic therapy involves the administration of a substance normally found in the body to enhance a metabolic reaction within the cell. This may be achieved in two ways. Firstly, for some systems a substance can be given to achieve greater than normal levels in the body so as to drive an enzymic reaction in a preferred direction. Secondly, metabolic therapy may be used to correct an absolute or relative deficiency of a cellular component. Thus, metabolic therapy differs greatly from most standard cardiovascular pharmacologic therapies such as the use of ACE Inhibitors, beta-blockers, statins and calcium channel antagonists that are given to block rather than enhance cellular processes.
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