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Related Experiment Video

Updated: Jul 13, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Infectious mononucleosis manifested as a cecal mass.

Dimitris C Keramidas¹, Dimitris Antoniou, Leonidas Marinos

¹Department of Pediatric Surgery, Mitera Maternity and Children's Hospital, 151 23 Athens, Greece. dimit940@otenet.gr

Journal of Pediatric Surgery

|July 10, 2007

Summary

An 11-year-old boy with a periappendiceal abscess was found to have an abnormal immune lesion mimicking lymphoma. This Epstein-Barr virus-associated condition involved an inflamed lymph node mass in the ileocecal region.

Related Experiment Videos

Last Updated: Jul 13, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Area of Science:

Pediatric Surgery
Gastrointestinal Pathology
Infectious Immunology

Background:

Appendiceal abscesses in children can present with complex abdominal masses.
Differentiating infectious and neoplastic processes in pediatric surgical cases is crucial.
The ileocecal region is a common site for both inflammatory and neoplastic lesions.

Observation:

A pediatric patient presented with symptoms suggestive of a periappendiceal abscess.
Laparotomy revealed a tumor-like mass in the ileocecal mesentery and cecum.
Histologic examination identified the mass as an inflamed lymph node block.

Findings:

The lesion was characterized by extensive acute inflammatory infiltration.
Histologic and immunophenotypic findings indicated an abnormal immune response.
The findings were consistent with an Epstein-Barr virus (EBV) infection mimicking a lymphomatous process.

Implications:

This case highlights the importance of considering infectious etiologies, such as EBV, in pediatric abdominal masses that mimic lymphoma.
Accurate diagnosis through comprehensive histologic and immunophenotypic analysis is essential for appropriate management.
Understanding these rare presentations aids in refining diagnostic and treatment strategies for pediatric surgical emergencies.