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Updated: Jul 13, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Salmonella pseudomembranous colitis.

Andrew Beck¹, Candice McNeil, George Abdelsayed

¹Northwestern University, USA.

Connecticut Medicine

|July 11, 2007

Summary

Pseudomembranous colitis, typically from antibiotics and Clostridium difficile, can rarely be caused by other pathogens. This case highlights Salmonella enterica as a rare cause of this condition.

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Area of Science:

Gastroenterology
Infectious Diseases
Microbiology

Background:

Pseudomembranous colitis is predominantly linked to antibiotic-induced disruption of gut microbiota.
Clostridium difficile is the most frequent causative agent identified in antibiotic-associated colitis.

Observation:

This report details a rare clinical presentation of pseudomembranous colitis.
The observed case involved infection with Salmonella enterica, an unusual pathogen for this condition.

Findings:

The study identifies Salmonella enterica as a rare cause of pseudomembranous colitis.
The clinical syndrome and pathological findings were identical to typical Clostridium difficile infections.

Implications:

This finding expands the differential diagnosis for pseudomembranous colitis beyond Clostridium difficile.
Clinicians should consider non-C. difficile pathogens in pseudomembranous colitis, especially in specific epidemiological contexts.