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Related Experiment Video

Updated: Jul 13, 2026

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research

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Virchow-Robin spaces at MR imaging.

Robert M Kwee¹, Thomas C Kwee

¹Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. rmkwee@gmail.com

Radiographics : a Review Publication of the Radiological Society of North America, Inc

|July 11, 2007

Summary

Virchow-Robin (VR) spaces are common brain imaging findings that increase with age. Understanding their typical appearance and locations helps differentiate them from various pathologies.

Area of Science:

Neurology
Radiology
Neuroimaging

Background:

Virchow-Robin (VR) spaces are perivascular spaces surrounding cerebral vessels.
They are visible in all age groups but increase in frequency and size with aging.
VR spaces exhibit signal intensity identical to cerebrospinal fluid on MRI.

Purpose of the Study:

To describe the characteristics and common locations of VR spaces.
To differentiate VR spaces from pathological conditions on neuroimaging.

Main Methods:

Review of magnetic resonance imaging (MRI) findings of VR spaces.
Analysis of signal intensity and anatomical distribution.
Comparison with various neurological pathologies.

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Main Results:

VR spaces are frequently observed, particularly in older individuals.
Three main types (Type I, II, III) are identified based on location.
Atypical presentations can occur, including large size and mass effect.

Conclusions:

VR spaces have characteristic imaging features and locations.
Knowledge of these features aids in distinguishing VR spaces from pathologies like lacunar infarcts or cysts.