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Updated: Jul 13, 2026
10:42
Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
Published on: July 6, 2022
Esophageal cancer: adjuvant therapy
1Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill-Cornell University Medical College, New York, NY 10021, USA.
Cancer Journal (Sudbury, Mass.)
|July 11, 2007
Summary
Preoperative chemoradiotherapy is the preferred treatment for locally advanced esophageal cancer in the US. This approach improves survival and curative resection rates, especially for adenocarcinoma.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Esophageal cancer is an aggressive malignancy in the US, with adenocarcinoma becoming predominant.
- Previous research explored chemotherapy and radiotherapy in perioperative settings.
Purpose of the Study:
- To review current treatment strategies for esophageal cancer.
- To highlight the role of chemoradiotherapy in managing locally advanced disease.
Main Methods:
- Review of existing clinical trials and treatment guidelines.
- Analysis of outcomes for different treatment modalities and histologies.
Main Results:
- Preoperative chemotherapy improves survival; adding radiotherapy enhances curative resection and reduces recurrence.
- Combined preoperative chemoradiotherapy is the preferred strategy for locally advanced esophageal cancer.
- Definitive chemoradiotherapy alone shows survival equivalence to surgery after chemoradiotherapy for squamous cell cancers, but surgery may improve local control.
Conclusions:
- Combined preoperative chemoradiotherapy is the standard of care for locally advanced esophageal cancer in the US.
- Postoperative treatment benefits adenocarcinoma of the gastroesophageal junction if preoperative therapy was not given.
- Future research focuses on novel chemotherapeutic agents and targeted therapies.
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