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Related Experiment Video

Updated: Jul 13, 2026

Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus

Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus

Published on: December 19, 2013

Variability of venom skin tests.

Arnon Goldberg¹

¹The Allergy and Clinical Immunology Unit, Meir Hospital, Kfar-Saba, Israel and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. arnong@clalit.org.il

Current Opinion in Allergy and Clinical Immunology

|July 11, 2007

Summary

Venom skin tests for allergy diagnosis show limited reproducibility, with one study reporting 66% for skin tests and 59% for IgE levels. Further research is needed to confirm these findings and understand venom allergy variability.

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Last Updated: Jul 13, 2026

Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus

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Published on: December 19, 2013

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Area of Science:

Allergy and Immunology
Diagnostic Testing
Clinical Research

Background:

Venom skin tests are crucial for diagnosing venom allergy.
Limited data exists on the reproducibility and variability of venom skin testing.

Purpose of the Study:

To review current knowledge on venom skin test variability.
To explore causes and clinical implications of this variability.
To identify situations where variability should be considered.

Main Methods:

Overview of existing literature on venom skin testing reproducibility.
Analysis of a recent study on skin test and serum venom-specific IgE reproducibility.
Consideration of clinical implications and future research directions.

Main Results:

A recent study indicated 66% reproducibility for skin tests and 59% for serum venom-specific IgE.
Reproducibility was assessed across two sessions for three venoms.
The validity of these findings requires further confirmation.

Conclusions:

The precise extent of venom skin test variability needs further determination.
Repeated skin tests and IgE measurements may be considered in specific clinical scenarios.
Understanding variability is essential before initiating venom immunotherapy.