Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Advances in mosquito allergy.

Zhikang Peng1, F Estelle R Simons

  • 1Department of Pediatrics and Child Health and Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada. zpeng@ms.umanitoba.ca

Current Opinion in Allergy and Clinical Immunology
|July 11, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The consistency of task-relevant and task-irrelevant vocal cues modulates speech judgments during dichotic listening.

Psychological research·2026
Same author

Perceiving female physical attractiveness and expressive traits from body features and body motion.

BMC psychology·2025
Same author

On How Vocal Cues Impact Dynamic Credibility Judgments: Mouse-Tracking Paradigm Examining Speaker Confidence and Gender Through Voice Morphing.

Journal of speech, language, and hearing research : JSLHR·2025
Same author

Optical biosensor based on weak measurement for ultra-sensitive detection of calreticulin in human serum.

Biomedical optics express·2024
Same author

Oxidation Analysis of l-Cysteine with a Chiral Sensor Based on Quantum Weak Measurement.

Analytical chemistry·2024
Same author

Gender context modulation on the self-enhancement effect of vocal attractiveness evaluation.

PsyCh journal·2021
Same journal

Biosimilars in allergology: an outline in pediatric patients.

Current opinion in allergy and clinical immunology·2026
Same journal

The immunogenetic landscape of systemic lupus erythematosus.

Current opinion in allergy and clinical immunology·2026
Same journal

Circadian control of innate immunity: molecular mechanisms and implications for allergic disorders.

Current opinion in allergy and clinical immunology·2026
Same journal

Probiotics in allergic disease: from adjunct supplement to immune-modifying strategy (2026 update).

Current opinion in allergy and clinical immunology·2026
Same journal

Updates on drug-induced anaphylaxis in children.

Current opinion in allergy and clinical immunology·2026
Same journal

Beta-lactam de-labelling as a core antimicrobial stewardship strategy in the era of the antimicrobial resistance pandemic: a narrative review.

Current opinion in allergy and clinical immunology·2026
See all related articles

Allergic reactions to mosquito bites are often underdiagnosed due to a lack of diagnostic tools. Recombinant allergens show promise for improving the diagnosis and treatment of mosquito allergy.

Area of Science:

  • Immunology
  • Allergology
  • Entomology

Background:

  • Mosquito bite allergies involve immunoglobulin E, immunoglobulin G, and T-lymphocyte responses to salivary allergens.
  • Natural desensitization can occur with prolonged exposure, but diagnosis and treatment are limited by the unavailability of salivary preparations.
  • Allergic reactions to mosquito bites are frequently underdiagnosed and undertreated.

Purpose of the Study:

  • To review allergic reactions to mosquito salivary allergens, immune mechanisms, desensitization, and immunotherapy.
  • To discuss the characteristics of salivary allergens and their recombinant forms.
  • To highlight the potential of recombinant allergens for improving diagnosis and treatment.

Main Methods:

  • Review of existing literature on mosquito allergy and salivary allergens.

Related Experiment Videos

  • Discussion of recombinant allergen development and application in diagnostics.
  • Analysis of immune responses, including non-immunoglobulin E-mediated pathways.

    • Main Results:

    • Development of biologically active recombinant saliva allergens, such as rAed a 2 from Aedes aegypti.
    • Successful expression, purification, and characterization of rAed a 2 for in-vitro diagnosis.
    • Identification of macrophage-inflammatory protein 2 and interleukin-10 in mosquito saliva-induced reactions.

    Conclusions:

    • Recombinant salivary allergens are expected to significantly enhance the diagnosis of mosquito allergy.
    • These advancements will also improve specific immunotherapy for individuals with systemic reactions to mosquito bites.
    • Further research into recombinant allergens will aid in better prevention and treatment strategies.