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Related Concept Videos

Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Sedatives and Hypnotics Drugs: Barbiturates01:20

Sedatives and Hypnotics Drugs: Barbiturates

Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A key...
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...

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Related Experiment Videos

Sedation in the emergency department.

Alan J Smally1, Thomas Anthony Nowicki

  • 1University of Connecticut Division of Emergency Medicine, Hartford Hospital, Hartford, CT 06102, USA. asmally@harthosp.org

Current Opinion in Anaesthesiology
|July 11, 2007
PubMed
Summary

Procedural sedation in the emergency department is increasingly common for various procedures. While complications can occur, clinically significant adverse events are rare, highlighting the overall safety and advantage of this practice.

Related Experiment Videos

Area of Science:

  • Emergency Medicine
  • Anesthesiology
  • Pharmacology

Background:

  • Moderate to deep sedation is increasingly utilized in emergency departments due to hospital crowding, anesthesia availability, and enhanced residency training.
  • Sedation is commonly employed for a range of procedures, with orthopedic interventions being the most frequent.
  • The growing trend reflects a shift towards managing more complex procedures within the emergency setting.

Purpose of the Study:

  • To review recent literature on the utilization and safety of sedation in emergency departments.
  • To analyze current practices, medications, monitoring techniques, and complication rates associated with emergency department procedural sedation.
  • To assess the benefits and challenges of sedation in the emergency medicine context.

Main Methods:

  • Literature review of studies published within the last year concerning emergency department sedation.
  • Analysis of reported medications, monitoring strategies, and patient outcomes.
  • Comparison of complication rates between prospective and retrospective studies.

Main Results:

  • Commonly used medications include propofol, etomidate, midazolam, fentanyl, ketamine, and nitrous oxide.
  • Standard monitoring includes cardiac monitoring, pulse oximetry, and capnography, though evidence for their necessity is often limited.
  • Complication rates appear higher in prospective studies, suggesting potential underreporting in retrospective series, yet significant complications remain uncommon.

Conclusions:

  • Emergency department procedural sedation is an advantageous practice.
  • Continued collaboration between anesthesiology and emergency medicine, guided by evidence-based medicine, is crucial for enhancing patient safety.
  • Further research and standardized protocols can optimize sedation practices in emergency settings.