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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...

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Related Experiment Video

Updated: Jul 13, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

Nitric oxide in the airways.

Glenis Scadding¹

¹Royal National TNE Hospital, London, UK. g.scadding@ucl.ac.uk

Current Opinion in Otolaryngology & Head and Neck Surgery

|July 11, 2007

Summary

Nasal nitric oxide is a valuable tool for diagnosing primary ciliary dyskinesia and monitoring chronic rhinosinusitis. Further research is needed to explore its role in airways defense and therapeutic applications.

Area of Science:

Otorhinolaryngology
Pulmonology
Biomedical Science

Background:

Nitric oxide (NO) is an emerging biomarker for lower airways inflammation.
Its application is expanding into otorhinolaryngological practice.

Purpose of the Study:

To review the basic facts about nitric oxide.
To highlight its clinical relevance in airway inflammation and otorhinolaryngology.

Main Methods:

Literature review of nitric oxide's role in respiratory and ENT conditions.
Analysis of diagnostic and therapeutic applications.

Main Results:

Nasal nitric oxide (nNO) is valid for diagnosing primary ciliary dyskinesia.
nNO aids in monitoring chronic rhinosinusitis therapy.

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A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

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Last Updated: Jul 13, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

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A humming maneuver with nNO measurement may reduce CT scan necessity.

Conclusions:

Nitric oxide is crucial for airway defense and acts as an inflammatory mediator.
Nasal breathing benefits may be partly explained by nasal nitric oxide.
Further research is warranted on NO production, ciliary beating, and therapeutic modulation.