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Transient decrease of sensory perception after thermoalgesic stimuli for quantitative sensory testing.

Pedro Schestatsky¹, Rebeca Algaba, Daniel Pérez

¹Department of Neurology, Hospital Clínic, Universitat de Barcelona, Villarroel 170, Barcelona, Spain.

|July 11, 2007

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Quantitative sensory testing (QST) involves applying heat stimuli. A brief pause between heat stimuli is needed to avoid reduced pain perception and delayed warm perception during QST.

Area of Science:

Neuroscience
Sensory Physiology

Background:

Transient decrease in neural circuit excitability after stimulation is known.
Its application to thermoalgesic stimuli in quantitative sensory testing (QST) is not well understood.

Purpose of the Study:

To investigate the effects of a conditioning thermoalgesic stimulus on the perception of a subsequent test stimulus.
To determine optimal interstimulus intervals (ISIs) for QST involving thermal stimuli.

Main Methods:

Utilized a Peltier thermode (12.5 cm(2)) with a ramp rate of 2°C/s.
Employed variable interstimulus intervals (ISIs) from 10 to 60 seconds.
Measured perception using an electronic visual analog scale.

Main Results:

Related Experiment Videos

No significant changes in the latency of pain perception were observed.

Latency of warm perception was significantly delayed at ISIs < 60 s.

Pain perception intensity was significantly reduced at ISIs < 60 s.

Conclusions:

Thermoalgesic stimuli cause transient saturation in warm and heat pain perception systems.
Recommend interstimulus intervals greater than 1 minute for consecutive thermoalgesic stimuli in QST.