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[Clinical studies on 10% cefdinir granules in pediatric infections]
1Department of Pediatrics, Oguchi Higashi General Hospital.
Insights
Ten percent cefdinir (CFDN) granules demonstrated 100% clinical efficacy in treating pediatric infections, with no observed side effects. This new oral cephalosporin preparation is a safe and effective option for children.
Area of Science:
- Pediatric Infectious Diseases
- Pharmacology
- Microbiology
Background:
- Cefdinir (CFDN) is an oral cephalosporin antibiotic.
- Pediatric infections require effective and safe treatment options.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of a 10% cefdinir (CFDN) granular preparation in children.
- To assess the antimicrobial activity of CFDN against common pediatric pathogens.
Main Methods:
- A total of 21 children with respiratory tract infections, urinary tract infections, or impetigo received 10% CFDN granules.
- Dosing ranged from 6.4-18 mg/kg/day, divided into three portions.
- Bacterial eradication rates and clinical outcomes were monitored.
Main Results:
- 100% clinical efficacy was observed, with 13 cases rated "excellent" and 7 "good".
- 19 bacterial strains from 7 species were eradicated (100% eradication rate).
- No side effects were reported in any child; one case showed eosinophilia.
Conclusions:
- 10% CFDN granules are a highly effective and safe treatment for pediatric infections.
- Both 10% and 5% CFDN granular preparations show promise for pediatric use.
Abstract:
Ten% cefdinir (CFDN, FK482) granular preparation, a new oral cephalosporin preparation intended for children, was given to children with various infections. The results obtained are summarized as follows. 1. Ten% CFDN granules were administered to a total of 21 children with upper or lower respiratory tract infections, urinary tract infections or infectious impetigo at daily doses of 6.4-18 mg/kg divided into 3 portions. Clinical efficacies were "excellent" in 13 patients, "good" in 7 patients and "unknown" in 1 patient (viral infection), hence an efficacy of 100% was obtained. 2. Bacteria identified in various disease cases included 19 strains of 7 species, and the eradication rate was 100%. 3. No side effects were noted in any of the children. Laboratory test results showed an abnormality in 1 case with eosinophilia. These results suggest that 10% CFDN granules as well as 5% CFDN granules may be a very useful and safe drug for the treatment of pediatric infections.