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Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction
Bei Chen1, Marcelo B Antunes, Steven Eau Claire
1Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
American Journal of Rhinology
|July 12, 2007
Summary
Chronic rhinosinusitis (CRS) impairs mucociliary clearance due to blunted ciliary responses. However, these impaired ciliary functions in CRS patients are reversible with ex vivo culturing.
Area of Science:
- Otorhinolaryngology
- Cell Biology
- Respiratory Medicine
Background:
- Chronic rhinosinusitis (CRS) is characterized by impaired sinonasal mucociliary clearance.
- This dysfunction leads to secretion stasis, infection, and inflammation.
- Previous studies showed blunted ciliary response to purinergic stimulation in CRS.
Purpose of the Study:
- Investigate if blunted ciliary response in CRS is unique to purinergic stimulation.
- Determine if CRS-associated mediators or genetic defects cause blunted ciliary function.
Main Methods:
- Analyzed ciliary stimulation (cholinergic, adrenergic, purinergic) in human sinonasal mucosal explants using microscopy and high-speed video.
- Assessed ciliary beat frequency of enzymatically dissociated ciliated cells cultured ex vivo.
Main Results:
- Ciliary responses to cholinergic and adrenergic stimulation were blunted in CRS explants.
- Most CRS samples exhibited a stimulatory ciliary phenotype within 36 hours of ex vivo culture.
Conclusions:
- CRS significantly affects sinonasal epithelial ciliary function, reducing mucociliary transport.
- The blunted ciliary response to environmental stimuli in CRS patients appears to be reversible.
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