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Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...

Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

Selectins

Selectins

Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

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Related Experiment Video

Updated: Jul 13, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Adhesion molecules in cutaneous immunity.

Robert C Fuhlbrigge¹, Carsten Weishaupt

¹Department of Dermatology, Harvard Medical School, Brigham and Women's Hospital, Eugene Braunwald Research Center, Boston, MA 02115, USA. rfuhlbrigge@partners.org

Seminars in Immunopathology

|July 12, 2007

Summary

Mammals possess a sophisticated skin immune system that identifies and eliminates pathogens. This review explores how adhesion molecules regulate immune cell movement in skin, impacting inflammatory skin diseases.

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Last Updated: Jul 13, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

Area of Science:

Immunology
Dermatology
Cell Biology

Background:

The skin acts as a crucial physical barrier against environmental pathogens.
Mammalian skin possesses an active immune surveillance system for pathogen detection and elimination.
Immune cell trafficking within the skin is essential for maintaining homeostasis and responding to inflammation.

Purpose of the Study:

To review the regulation and function of adhesion molecules in cutaneous immune surveillance.
To explore the role of adhesion molecules in the immunopathology of inflammatory skin diseases.

Main Methods:

This is a review article, synthesizing existing research.
Literature search and analysis of studies on skin immunity and adhesion molecules.
Discussion of regulatory mechanisms and functional roles.

Main Results:

Adhesion molecules are critical regulators of immune cell movement within the skin.
Dysregulation of these molecules contributes to inflammatory skin conditions.
Understanding these molecules offers insights into disease pathogenesis.

Conclusions:

Adhesion molecules are key players in skin immune surveillance and response.
Targeting adhesion molecules may offer therapeutic strategies for inflammatory skin diseases.
Further research is warranted to fully elucidate their complex roles.