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Updated: Jul 13, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
[Pharmacological treatment of neurogenic detrusor hyperactivity: intrathecal drugs]
P Denys1, A Even Schneider, O Remy-Neris
1Service de Médecine Physique et de Réadaptation, Raymond Poincaré, Université Versailles Saint-Quentin en Yvelines, Bordeaux, France. pierre.denys@rpc.aphp.fr
Abstract:
Intrathecal clonidine has been tested in spinal cord injury patients not supporting or resistant to anticholinergic drugs. Although the acute effect of clonidine on urodynamic parameters was satisfactory, cardiovascular adverse effects limited the long-term efficacy of this treatment. Intrathecal baclofen has a limited effect on overactive bladder in patients with spinal spasticity, but can modify the quality of erections and induce an incapacity to trigger ejaculation by vibratory penile stimulation.
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