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Related Experiment Video

Updated: Jul 13, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Osteosarcoma with skeletal muscle metastasis.

Kenji Yamada¹, Yasushi Yatabe, Hideshi Sugiura

¹Department of Orthopaedics, Aichi Cancer Center Hospital, Chikusa, Nagoya, Japan. kyamada@aichi-cc.jp

Archives of Orthopaedic and Trauma Surgery

|July 12, 2007

Summary

This case study highlights a rare instance of osteosarcoma soft tissue metastasis. A young man achieved long-term remission after surgical removal of skeletal muscle metastasis without chemotherapy.

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Last Updated: Jul 13, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

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Published on: October 28, 2021

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Area of Science:

Oncology
Orthopedic Oncology
Skeletal Muscle Metastasis

Background:

Osteosarcoma commonly metastasizes to lungs and bone.
Soft tissue metastasis from osteosarcoma is exceptionally rare.
Long-term survival following soft tissue metastasis is infrequently reported.

Observation:

An 18-year-old male presented with a solitary skeletal muscle metastasis.
This occurred as the second relapse of osteosarcoma.
The metastasis was located in the right vastus lateralis muscle.

Findings:

The patient underwent complete surgical excision of the metastasis.
No adjuvant chemotherapy was administered post-surgery.
The patient has remained disease-free for over 34 months.

Implications:

This case suggests that surgical resection can be a viable option for localized soft tissue metastasis in osteosarcoma.
It challenges the conventional treatment paradigms for rare metastatic patterns.
Further research into surgical management of soft tissue osteosarcoma metastasis is warranted.