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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jul 13, 2026

CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells

CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells

Published on: June 2, 2022

Ceramide: from embryos to tumors.

Iaroslav A Savtchouk¹, Floyd J Mattie, Anne A Ollis

¹Department of Biology, Pennsylvania State University, University Park, PA 16802, USA. ixs138@psu.edu

Science'S STKE : Signal Transduction Knowledge Environment

|July 12, 2007

Summary

Ceramides are crucial lipids in apoptosis. Understanding ceramide metabolism and resistance is key for developing new cancer therapies targeting cancer cell death.

Area of Science:

Lipid Metabolism
Cellular Biology
Oncology

Background:

Ceramides are ubiquitous lipids vital for apoptotic signaling.
Therapeutic agents targeting ceramide-dependent apoptosis in cancer cells exist.
Enzymes in ceramide metabolism are emerging as potential cancer therapy targets.

Purpose of the Study:

To explore the role of ceramides in apoptosis.
To understand ceramide metabolism in cancer therapy.
To investigate ceramide's role in multidrug resistance and embryonic development.

Main Methods:

Review of current literature on ceramide metabolism and apoptosis.
Analysis of therapeutic strategies targeting ceramide pathways.
Examination of ceramide's role in drug resistance and development.

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Last Updated: Jul 13, 2026

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Published on: September 13, 2019

Main Results:

Evasion of ceramide-dependent apoptosis is critical in early embryonic development.
Ceramide apoptosis evasion is a significant mechanism in multidrug resistance.
Ceramide-based cancer treatments show promise but require further research.

Conclusions:

Further understanding of ceramide's role in apoptosis is needed, especially concerning ceramide-resistant tumors.
Targeting ceramide metabolism offers a promising avenue for cancer therapy development.
Ceramide's dual role in development and drug resistance highlights its complex involvement in cellular processes.