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Characteristic changes in platelet-large cell ratio, lactate dehydrogenase and C-reactive protein in

Osamu Kabutomori1, Yuzuru Kanakura, Yoshinori Iwatani

  • 1Central Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan. kabutomori@hp-lab.med.osaka-u.ac.jp

Acta Haematologica
|July 12, 2007
PubMed

We examined the clinical usefulness of 3 parameters of routine laboratory tests [platelet-large cell ratio (P-LCR), lactate dehydrogenase (LDH) and C-reactive protein (CRP)] in 84 patients with thrombocytosis-related diseases (reactive thrombocytosis, chronic myeloid leukemia, essential thrombocythemia and polycythemia vera). These thrombocytosis-related diseases were characterized using the 3 parameters P-LCR, LDH and CRP as follows: high P-LCR and high LDH in chronic myeloid leukemia; high CRP in reactive thrombocytosis; slightly high P-LCR and high LDH in essential thrombocythemia and polycythemia vera. For essential thrombocythemia and polycythemia vera, levels of P-LCR and CRP were nearly identical, but the LDH level in essential thrombocythemia was significantly higher than in polycythemia vera. These characteristics of P-LCR, LDH and CRP may be useful for simple and very rough differentiation of the thrombocytosis-related disease mentioned above.

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