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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
Peripheral nervous system involvement in patients with Behçet disease
Huseyin Tugrul Atasoy1, Tugba Oruc Tunc, Aysun Eroglu Unal
1Neurology Department, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey. tugrul.atasoy@gmail.com
The Neurologist
|July 12, 2007
Summary
Peripheral nervous system involvement in Behçet disease (BD) is often asymptomatic and detectable via electrophysiological tests. Axonal polyneuropathy is a potential manifestation in BD patients.
Area of Science:
- Neurology
- Immunology
- Genetics
Background:
- Central nervous system (CNS) involvement is recognized in Behçet disease (BD).
- Peripheral nervous system (PNS) involvement in BD remains less understood.
- This study investigates the prevalence and characteristics of PNS involvement in BD patients.
Observation:
- Sixty-nine BD patients were evaluated through clinical examinations and electrophysiological studies.
- Other potential causes of peripheral neuropathy were systematically excluded.
- Nerve conduction studies were performed to assess nerve function.
Findings:
- Peripheral nervous system involvement was identified in 13 out of 69 BD patients.
- In 5 patients, clinically evident peripheral nerve involvement manifested as sensorimotor or sensory axonal neuropathies.
- Asymptomatic median nerve conduction delays were observed in 3 patients, highlighting subclinical PNS involvement.
Implications:
- Axonal polyneuropathy is a potential neurological complication of Behçet disease.
- Electrophysiological examinations can detect subclinical peripheral nervous system involvement in asymptomatic BD patients.
- These findings underscore the importance of comprehensive neurological assessment in BD management.
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