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Selenium deficiency and Balkan endemic nephropathy.
1Faculty of Mining and Geology, Belgrade, Yugoslavia.
Kidney International. Supplement
|November 1, 1991
Summary
Yugoslavia exhibits widespread selenium deficiency across various environmental samples and human tissues. Extremely low selenium levels in grains and human samples suggest a potential contributing factor to Balkan endemic nephropathy.
Area of Science:
- Environmental Science
- Human Health
- Geochemistry
Background:
- Selenium (Se) deficiency has been implicated in various health issues.
- Understanding regional Se levels is crucial for public health assessments.
- Balkan endemic nephropathy (BEN) is a serious kidney disease affecting specific regions.
Purpose of the Study:
- To summarize available data on selenium (Se) distribution in Yugoslavia.
- To investigate potential links between environmental Se levels and human Se status.
- To explore the role of Se deficiency in the etiology of Balkan endemic nephropathy.
Main Methods:
- Analysis of Se concentrations in stream sediments, rocks, and soils.
- Determination of Se levels in cereal crops.
- Measurement of Se concentrations in human serum and scalp hair samples from various Yugoslavian regions.
Main Results:
- Low Se concentrations were observed in human tissues (serum and hair) across both endemic and nonendemic areas.
- Se levels in grains, human serum, and hair were found to be extremely low in some regions, comparable to known low-Se zones.
- Environmental samples (sediments, rocks, soils) also indicated widespread low Se availability.
Conclusions:
- Widespread selenium deficiency is evident in Yugoslavia, affecting both the environment and the human population.
- Extremely low Se intake, particularly in endemic regions, may be a significant predisposing factor for Balkan endemic nephropathy.
- Further research is warranted to confirm the direct causal link between Se deficiency and BEN development.