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Multidisciplinary fatigue management programme in multiple sclerosis: a randomized clinical trial.

D Kos1, M Duportail, Mb D'hooghe

  • 1Department of Rehabilitation Research, Vrije Universiteit Brussel, Brussels, Belgium, Department of Occupational Therapy, National MS Centre, Melsbroek, Belgium. Daphne.Kos@vub.ac.be

Multiple Sclerosis (Houndmills, Basingstoke, England)
|July 12, 2007
PubMed
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The multidisciplinary fatigue management programme (MFMP) did not show significant efficacy in reducing fatigue impact in multiple sclerosis (MS) patients compared to a placebo. While some participants improved, the overall results suggest limited benefit for MS fatigue management.

Area of Science:

  • Neurology
  • Rehabilitation Medicine

Background:

  • Fatigue is a significant and common symptom in multiple sclerosis (MS).
  • Effective management strategies for MS-related fatigue are crucial for improving patient quality of life.

Purpose of the Study:

  • To evaluate the efficacy of a multidisciplinary fatigue management programme (MFMP) for individuals with MS.
  • To compare the MFMP's effectiveness against a placebo intervention.

Main Methods:

  • Fifty-one MS patients were randomized into two groups: one receiving the MFMP, the other a placebo intervention followed by the MFMP.
  • Assessments included the Modified Fatigue Impact Scale (MFIS), Fatigue Severity Scale (FSS), MS Self-Efficacy scale (MSSE), Mental Health Inventory (MHI), and Impact on Participation and Autonomy (IPA) at baseline, 3 weeks, and 6 months.

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Main Results:

  • The MFIS showed a significant change over time, but this was similar between groups.
  • A clinically relevant reduction in MFIS score was observed in 17% after MFMP versus 44% after placebo (P=0.06).
  • No significant changes were found for FSS, MSSE, MHI, and IPA in either group.

Conclusions:

  • The MFMP demonstrated no significant efficacy in reducing the impact of fatigue compared to a placebo intervention in MS patients.
  • While an additional effect was noted, the overall findings suggest limited benefit of the MFMP for MS-related fatigue.