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Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma

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Vulvar primitive melanoma and sentinel lymph node: case report.

E Migliano¹, C Monarca, L Mariani

¹Department of Plastic Surgery, IRCCS San Gallicano Institute IFO, Rome, Italy.

European Journal of Gynaecological Oncology

|July 13, 2007

Summary

This study presents a case of vulvar melanoma treated with radical vulvectomy and radio-controlled lymphadenectomy. The patient achieved a 36-month recurrence-free survival, demonstrating successful treatment outcomes for this rare cancer.

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Area of Science:

Gynecologic Oncology
Surgical Oncology
Dermatology

Background:

Vulvar melanoma is a rare malignancy with significant morbidity.
Early diagnosis and appropriate surgical management are crucial for patient outcomes.

Observation:

A 54-year-old woman presented with vulvar melanoma originating from a melanocytic lesion.
The lesion extended from the clitoris to the left labium minor without clinical lymph node involvement.

Findings:

Incisional biopsy confirmed melanoma 4 mm in thickness.
Preoperative lymphoscintigraphy using 99m Tc Nanocoll guided surgical planning.
Surgical treatment involved radio-controlled lymphadenectomy and radical vulvectomy.
Reconstruction utilized bilateral subgluteus soft-tissue flaps, with urethral and vaginal stump anastomosis.
The patient remained disease-free at 36 months post-surgery.

Implications:

This case highlights the successful application of a multidisciplinary approach in managing vulvar melanoma.
Radio-controlled lymphadenectomy and flap reconstruction offer viable options for surgical treatment and defect repair.
Long-term surveillance is essential for patients treated for vulvar melanoma.