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Updated: Jul 13, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
Published on: January 30, 2026
The image analysis of colour changes of different human tissues in the relation to the age. Part 1. Methodological
1Institute of Forensic Medicine and Toxicology, First Faculty of Medicine, Charles University and General Teaching Hospital,n Prague, Czech Republic. pilin@lf1.cuni.cz
Abstract:
The human age for medico-legal purposes is usually estimated from hard tissues like bones and teeth. Only little attention was paid to soft tissues most probably due to the lack of detectable age changes. This study deals with colour changes of human tissue from intervertebral discs, Achilles tendon and rib cartilage in the relation to the age. The image analysis of colour of investigated tissue samples was performed. The values of intensities of channels RGB (MeanRed, MeanGreen, and MeanBlue) and parameters from the IHS system (MeanSaturation, HueTypical, HueVariation, BrightVariation and MeanBrightness) were evaluated. The results confirm that colour changes of some tissues can be used for age estimation.
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