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Related Experiment Videos

The Schistosoma mansoni transcriptome: an update.

Guilherme Oliveira1

  • 1Laboratory of Cellular and Molecular Parasitology, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima 1715, Belo Horizonte, MG 30190-002, Brazil. oliveira@cpqrr.fiocruz.br

Experimental Parasitology
|July 13, 2007
PubMed
Summary
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Large-scale expressed sequence tag (EST) sequencing aids schistosome research by enabling gene discovery and improving genome annotation. This approach also helps identify potential drug and vaccine targets for Schistosoma mansoni and Schistosoma japonicum.

Area of Science:

  • Parasitology
  • Genomics
  • Bioinformatics

Background:

  • Schistosome parasites (Schistosoma mansoni and Schistosoma japonicum) cause significant human disease.
  • Large-scale expressed sequence tag (EST) sequencing projects have been undertaken for these parasites.
  • EST data provides valuable insights into the schistosome transcriptome.

Purpose of the Study:

  • To review recent accomplishments in schistosome EST sequencing.
  • To discuss the utility of EST data for gene discovery, model development, genome annotation, and SNP analysis.
  • To explore EST applications in identifying drug and vaccine targets.

Main Methods:

  • Review of published literature on schistosome EST sequencing projects.
  • Analysis of EST data for gene discovery and functional annotation.

Related Experiment Videos

  • Exploration of EST-derived information for transcript variants and SNP identification.

    • Main Results:

    • EST sequencing has significantly advanced schistosome research.
    • EST data facilitates gene discovery, genome annotation, and SNP analysis.
    • ESTs are useful for studying transcriptome variations and assigning functions to unknown genes.

    Conclusions:

    • EST sequencing is a powerful tool for schistosome genomics and transcriptomics.
    • Further data mining of ESTs can reveal novel drug and vaccine targets.
    • Continued EST analysis will enhance our understanding and control of schistosomiasis.