Jove
Visualize
Contact Us

Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung Fibrosis.

bioRxiv : the preprint server for biology·2026
Same author

A CD57+CD8+ T cell subset links T cell cytotoxicity to fibrotic lung disease in systemic sclerosis.

The Journal of clinical investigation·2026
Same author

Rebalancing Inflammation in Arthritis: PEPITEM as a Restorer of Immune Regulation.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Single-Cell Analysis Reveals Peripheral Helper T Cells in Rheumatoid Arthritis-Related Interstitial Lung Disease.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Disease modifying biomaterials for modulating mechanical allodynia in a preclinical model of rheumatoid arthritis.

Bioengineering & translational medicine·2025
Same author

T<sub>H</sub>17 cells converted into exT<sub>H</sub>17 cells sustain rheumatoid-like IL-17-independent inflammatory arthritis.

Science immunology·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 13, 2026

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

Association between PTPN22 and endometriosis.

Maria Ammendola1, Nunzio Bottini, Adalgisa Pietropolli

  • 1Division of Gynecology and Obstetrics, Department of Surgery, Hospital University of Rome Tor Vergata, School of Medicine, Rome, Italy.

Fertility and Sterility
|July 13, 2007
PubMed
Summary

The PTPN22 gene variant (PTPN22(*)T) increases women's susceptibility to endometriosis, a condition linked to shared autoimmunity. This finding identifies a potential genetic marker for endometriosis risk.

More Related Videos

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
08:07

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Related Experiment Videos

Last Updated: Jul 13, 2026

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
08:07

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Area of Science:

  • Genetics
  • Immunology
  • Gynecology

Background:

  • The PTPN22 gene is implicated in various autoimmune diseases.
  • Shared autoimmunity genes are candidates for complex conditions like endometriosis.
  • Endometriosis is a prevalent gynecological disorder with an unclear etiology.

Purpose of the Study:

  • To investigate the association between the PTPN22 gene variant and endometriosis risk.
  • To evaluate PTPN22 as a potential genetic marker for endometriosis.

Main Methods:

  • Case-control study comparing endometriosis patients and healthy controls.
  • Genotyping for the PTPN22(*)T variant.

Main Results:

  • Female carriers of the PTPN22(*)T variant showed significantly higher susceptibility to endometriosis.
  • A statistically significant association was observed between the PTPN22(*)T variant and endometriosis.

Conclusions:

  • The PTPN22(*)T variant is a risk factor for endometriosis.
  • PTPN22 is a potential shared-autoimmunity gene contributing to endometriosis pathogenesis.
  • Genetic screening of PTPN22 may aid in identifying individuals at higher risk for endometriosis.