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Lymphomas of the head and neck in the pediatric population

Jong-Lyel Roh1, Jooryung Huh, Hyung Nam Moon

  • 1Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Pungnap-dong, Songpa-gu, Seoul 138-736, Republic of Korea. rohjl@amc.seoul.kr

International Journal of Pediatric Otorhinolaryngology
|July 13, 2007
PubMed

Insights

Pediatric head and neck lymphomas occurred in 42.5% of Asian children. Advanced stage and lack of early remission were poor prognostic factors for survival in these head and neck lymphoma patients.

Area of Science:

  • Pediatric oncology
  • Hematology
  • Head and neck cancer research

Background:

  • Limited data exists on head and neck (HN) lymphomas in pediatric Asian populations.
  • Understanding incidence and survival is crucial for this demographic.

Purpose of the Study:

  • To determine the incidence of HN involvement in pediatric lymphomas.
  • To identify prognostic factors for survival in these patients.

Main Methods:

  • Retrospective review of medical records for children (0-14 years) with untreated HN lymphomas.
  • Comparison of clinicopathologic characteristics and outcomes between Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL).
  • Investigation of potential prognostic factors for patient survival.

Main Results:

  • 45 out of 106 (42.5%) pediatric lymphoma patients had HN involvement.
  • Non-Hodgkin's lymphoma (NHL) cases (n=37) presented more aggressively than Hodgkin's disease (HD) (n=8).
  • Five-year disease-free survival was 76.0%; advanced stage and lack of complete remission after 3 chemotherapy cycles were poor prognostic indicators.

Conclusions:

  • Head and neck involvement in pediatric lymphomas was observed in 42.5% of the study population.
  • Disease stage and early chemotherapy response are independent prognostic factors for survival in pediatric HN lymphomas.
Abstract

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